Benzathine Benzylpenicillin

There are more deal around the globe who would benefit from an chisel inable drug intentional to release small amounts of medication everyplace the course of a month. This is oddly necessary for people suffering from bacterial meningitis as they are infallible to receive injections on a regular basis. Additionally, there are uncounted other populations that would benefit from the availability of injectable medication. This type of medication dispension is recyclable for third world populations since they dont nonplus access to doctors on a regular basis.An injection that lasts for one month would fix that these people were receiving necessary medication on a regular basis. At the uni salmagundi time, an injectable form of medication increases patient compliance since they are merely responsible for getting the injection once a month or else of on a more regular basis. Similarly, injectable forms of medication part with patients to receive invariant therapeutic levels of drug maintenance that ensures they get well.Finally, making medication available in injection form eliminates the need to preserve drugs and also reduces the number of trips a patient must perk up to a clinic to receive necessary medication. Therefore, this investigator aims to look at benzathine penicillin G and its service as an injectable drug. The lab already purchases benzathine benzylpenicillin but it is not in pure form. As a result, the descent of this research worker would be to coat the benzathine benzylpenicillin with different polymers in order to sluggish obliterate the disintegration wait on.If successful, this process would improve the lives of sick people all over the world who are indispensable to receive frequent doses of penicillin. Penicillin is known to be unstable in liquid formations (Ogunleye, et al, 2004). Therefore, the first goal this researcher would tolerate is to work with one type of polymer that uses heat rather than water. This polyme r get out be used to coat the penicillin so particles will not clump up. It is inbred to develop a way to keep penicillin particles from clumping so they can be released on a consistent basis after the initial injection.Further, benzathine benzylpenicillin will be injected using a needle and PVA is hydrophilic so clumping must be avoided in order to successfully inject the medication. The polymer this researcher will use is called polyvinyl alcohol. Establishing a way to prevent penicillin from clumping will contribute much to the research being conducted around the possibilities and benefits of using injectable benzathine benzylpenicillin. The second aim this researcher has is to develop a way to s humbled down the dissolving process of the benzathine benzylpenicillin in order to ensure that it releases constant dosages for an entire month.The main goal in slack offing the dissolving process is to achieve a minimum level of concentration in order for the drug to be effective at a low level for a very long time. Discovering a way to slow this process is essential for may patients, particularly those suffering from bacterial meningitis because benzathine benzylpenicillin cannot be given orally as the gastric acid and concentration of the intestinal tract is too slow to deem the oral form of the drug effective (Shaheen, 2004).There are several steps this researcher will take in preparing penicillin to be coated in order to make an injectible form of benzathine benzylpenicillin successful and worthwhile. After successfully determining the polymer concentrations that would be most effective, this researcher would use a fluid bed coater to practice the polymers to the penicillin. A fluid bed coater looks like an spinning top down nursing bottle where the drug particles are dried as they travel in a clockwise circular motion. The penicillin will go into the machine and the polymers will go into a spray gun.The penicillin will be blown up into the upside down bottle and as it passes the spray gun it will be coated with the two different polymers. The inside of the bottle is hot so that the penicillin can dry before being sprayed with the polymers subsequent times. This process goes on until the researcher stops the machine. This allows the researcher to control how much polymer is allowed to coat the penicillin. The utmost step in this process is a dissolution test on the polymer coated penicillin. This researcher will place the penicillin in water (used as a medium of blood) and stir until dissolved.Then, this researcher will use a visible spectrospectry to determine the concentration of the drug in the water. This process allows the researcher to figure out how much of the drug was dissolved ground on the amount of polymer coating the penicillin. In order to calculate the exact concentration, a sample of the water is placed in a cubbet and a UV ignite is shined on the sample. Concentration rates are determined based on how much ligh t is able to come through, what type of light is coming through and the wavelength of the light coming through.Any given molecule has a characteristic spectrum for a specific concentration of the drug, so by facial expression at the spectrum you can find drug concentration. This researcher is right for the job based on an in depth understanding of benzathine benzylpenicillin and the process it must go through to become safe and effective as an injectible drug. Additionally, this researcher is enthusiastic about the possibilities such an injectible drug will have to positively impact the lives of many people required to take constant doses of medication.The penicillin family of medication is an important tool in the arsenal for fighting unhealthiness (Wright, 1999). They are of low toxicity, they are highly effective and they are intimately distributed through the body (Wright, 1999). This work wont be fulfil quickly and there will be challenges along the way. However, this resear cher is willing to persevere in order to discover new and innovative ship canal to make drug administration easier and more effective for people required to take benzathine benzylpenicillin.When a correct mixture of polymers is discovered and dissolution is slow, this researcher will consider the project a success. Ogunleye, D. S. Kolawale, J. A. Okaroh, I. & Okeniyi, S. O. Effects of Thawing Methods on the Stability of Cloxacillin Sodium and Benzathine Benzyl Penicillin Injections. Nigerian Journal of Health and biomedical Sciences 2004, 3, 51 55. Shaheen, Rubina. Penicillins. Indian Journal for the Practicing Doctor 2004, 1, 11 12. Wright, Alan J. The Penicillins. The Mayo Clinic Proceedings, 1999, 74, 290 307.